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| Escherichia virus Lambda | |
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| Electron micrograph of a virus particle of species Escherichia virus Lambda | |
Virus classification 
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| (unranked): | Virus |
| Realm: | Duplodnaviria |
| Kingdom: | Heunggongvirae |
| Phylum: | Uroviricota |
| Class: | Caudoviricetes |
| Order: | Caudovirales |
| Family: | Siphoviridae |
| Genus: | Lambdavirus |
| Species: | Escherichia virus Lambda
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Enterobacteria phage λ (lambda phage, coliphage λ, officially Escherichia virus Lambda) is a bacterial virus, or bacteriophage, that infects the bacterial species Escherichia coli (E. coli). It was discovered by Esther Lederberg in 1950.[2] The wild type of this virus has a temperate life cycle that allows it to either reside within the genome of its host through lysogeny or enter into a lytic phase, during which it kills and lyses the cell to produce offspring. Lambda strains, mutated at specific sites, are unable to lysogenize cells; instead, they grow and enter the lytic cycle after superinfecting an already lysogenized cell.[3]
The phage particle consists of a head (also known as a capsid),[4] a tail, and tail fibers (see image of virus below). The head contains the phage's double-strand linear DNA genome. During infections, the phage particle recognizes and binds to its host, E. coli, causing DNA in the head of the phage to be ejected through the tail into the cytoplasm of the bacterial cell. Usually, a "lytic cycle" ensues, where the lambda DNA is replicated and new phage particles are produced within the cell. This is followed by cell lysis, releasing the cell contents, including virions that have been assembled, into the environment. However, under certain conditions, the phage DNA may integrate itself into the host cell chromosome in the lysogenic pathway. In this state, the λ DNA is called a prophage and stays resident within the host's genome without apparent harm to the host. The host is termed a lysogen when a prophage is present. This prophage may enter the lytic cycle when the lysogen enters a stressed condition.
- ^ Padilla-Sanchez V (2021-07-16). "Bacteriophage Lambda Structural Model at Atomic Resolution". doi:10.5281/zenodo.5134493. Retrieved 2021-07-24.
- ^ Lederberg E (January 1950). "Lysogenicity in Escherichia coli strain K-12". Microbial Genetics Bulletin. 1: 5–8.; followed by Lederberg EM, Lederberg J (January 1953). "Genetic Studies of Lysogenicity in Escherichia Coli". Genetics. 38 (1): 51–64. doi:10.1093/genetics/38.1.51. PMC 1209586. PMID 17247421.
- ^ Griffiths A, Miller J, Suzuki D, Lewontin R, Gelbart W (2000). An Introduction to Genetic Analysis (7th ed.). New York: W. H. Freeman. ISBN 978-0-7167-3520-5. Retrieved 19 May 2017.
- ^ Wang C, Zeng J, Wang J (April 2022). "Structural basis of bacteriophage lambda capsid maturation". Structure. 30 (4): 637–645.e3. doi:10.1016/j.str.2021.12.009. PMID 35026161. S2CID 245933331.